Top 20 World Deadliest Pandemics

Image by fernando zhiminaicela from Pixabay 

Pandemic         Disease                             Death toll

1. Black Death Bubonic plague             75–200 million

2. Spanish flu Influenza A/H1N1             17–100 million

3. Plague of Justinian Bubonic plague     15–100 million

4. HIV/AIDS pandemic HIV/AIDS     35 million+ (as of 2018)

5. Third plague pandemic Plague             12–15 million

6. Cocoliztli Epidemic of 1545–1548 Cocoliztli   5–15 million

7. Antonine Plague Smallpox or measles     5–10 million

8. 1520 Mexico smallpox epidemic Smallpox     5–8 million

9. COVID-19 pandemic COVID-19             3.8 million+ (reported on  June 2021)

10. 1918–1922 Russia typhus epidemic Typhus 2–3 million

11. 1957–1958 influenza pandemic Influenza A/H2N2 1–4 million

12. Hong Kong flu Influenza A/H3N2                     1–4 million

13. Cocoliztli epidemic of 1576 Cocoliztli             2–2.5 million

14. 735–737 Japanese smallpox epidemic Smallpox     2 million

15. 1772–1773 Persian Plague Bubonic plague     2 million

16. Naples Plague Plague                                             1.25 million

17. Third cholera pandemic Cholera                             1 million+

18. 1629–1631 Italian plague Bubonic plague     1 million

19. 1889–1890 flu pandemic Influenza                     1 million